Endocrinology and Metabolism

Patricia Deanna D. Maningat (Maningat PDD)

2 Articles

Clinical Study
Well-Differentiated Thyroid Cancer: The Philippine General Hospital Experience: Tom Edward N. Lo, Abigail T. Uy, Patricia Deanna D. Maningat; Endocrinol Metab. 2016;31(1):72-79. Published online March 16, 2016; DOI: https://doi.org/10.3803/EnM.2016.31.1.72

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52 Download
20 Web of Science
14 Crossref

Background

Well-differentiated thyroid cancer (WDTC) is the most common form of thyroid malignancy. While it is typically associated with good prognosis, it may exhibit higher recurrence and mortality rates in selected groups, particularly Filipinos. This paper aims to describe the experience of a Philippine Hospital in managing patients with differentiated thyroid cancer.

Methods

We performed a retrospective cohort study of 723 patients with WDTC (649 papillary and 79 follicular), evaluating the clinicopathologic profiles, ultrasound features, management received, tumor recurrence, and eventual outcome over a mean follow-up period of 5 years.

Results

The mean age at diagnosis was 44±13 years (range, 18 to 82), with a majority of cases occurring in the younger age group (<45 years). Most tumors were between 2 and 4 cm in size. The majority of papillary thyroid cancers (PTCs, 63.2%) and follicular thyroid cancers (FTCs, 54.4%) initially presented as stage 1, with a greater proportion of FTC cases (12.7% vs. 3.7%) presenting with distant metastases. Nodal metastases at presentation were more frequent among patients with PTC (29.9% vs. 7.6%). A majority of cases were treated by complete thyroidectomy, followed by radioactive iodine therapy and thyroid stimulating hormone suppression, resulting in a disease-free state. Excluding patients with distant metastases at presentation, the recurrence rates for papillary and FTC were 30.1% and 18.8%, respectively.

Conclusion

Overall, PTC among Filipinos was associated with a more aggressive and recurrent behavior. FTC among Filipinos appeared to behave similarly with other racial groups.

Citations

Citations to this article as recorded by

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Cureus.2024;[Epub] CrossRef
Behaviour and epidemiology of differentiated thyroid cancer among filipinos in and outside the Philippines: Comparison between Qatar, Canada and Philippines
Mohamed Said Ghali, Walid El Ansari, Abdelrahman Abdelaal, Mohamed S. Al Hassan
Annals of Medicine and Surgery.2022; 81: 104202. CrossRef
Discrimination of malignant from benign thyroid lesions through neural networks using FTIR signals obtained from tissues
Abegail Santillan, Rock Christian Tomas, Ruth Bangaoil, Rolando Lopez, Maria Honolina Gomez, Allan Fellizar, Antonio Lim, Lorenzo Abanilla, Maria Cristina Ramos, Leonardo Guevarra, Pia Marie Albano
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Decline in radioiodine use but not total thyroidectomy in thyroid cancer patients treated in the United Arab Emirates - A retrospective study
Malik Azhar, Faisal Aziz, Salama Almuhairi, Mohammad Alfelasi, Ali Elhouni, Rizwan Syed, Humaid O. Al-Shamsi, Khaled M. Aldahmani
Annals of Medicine and Surgery.2021; 64: 102203. CrossRef
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David J. Lubin, Caleb Tsetse, Mohammad S. Khorasani, Massoud Allahyari, Mary McGrath
World Journal of Nuclear Medicine.2021; 20(03): 253. CrossRef
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Kristiana Rood, Khodeza Begum, Hanmin Wang, Yan C. Wangworawat, Ryan Davis, Celina R. Yamauchi, Mia C. Perez, Alfred A. Simental, Ria T. Laxa, Charles Wang, Sourav Roy, Salma Khan
Current Oncology.2021; 28(5): 3610. CrossRef
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Luisa E. Jacomina, JC Kennetth M. Jacinto, Lester Bryan A. Co, Kelvin Ken L. Yu, Ryan Anthony F. Agas, Jayson L. Co, Michael Benedict A. Mejia
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Michelle‐Linh T. Nguyen, Jiaqi Hu, Katherine G. Hastings, Eric J. Daza, Mark R. Cullen, Lisa A. Orloff, Latha P. Palaniappan
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Articles inEndocrinology and Metabolismin 2016
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Endocrinology and Metabolism.2017; 32(1): 62. CrossRef
THYROID CANCER: A RETROSPECTIVE ANALYSIS
Javan N G, Jitendra N, Ibomcha Singh K H, Phungreikan N, Sanatomba Singh Y, Wormi Sharon
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Endocrinology and Metabolism.2016; 31(1): 62. CrossRef

Clinical Study
Risk Factors for Recurrence in Filipinos with Well-Differentiated Thyroid Cancer: Tom Edward Ngo Lo, Abigail Uy Canto, Patricia Deanna D. Maningat; Endocrinol Metab. 2015;30(4):543-550. Published online December 31, 2015; DOI: https://doi.org/10.3803/EnM.2015.30.4.543

3,642 View
51 Download
11 Web of Science
10 Crossref

Abstract PDF PubReader

Background

The incidence of well-differentiated thyroid cancer (WDTC) has increased in recent years. Despite its excellent prognosis, increasing morbidity from recurrent diseases continues to affect long-term outcomes. Among at-risk populations, Filipinos have the highest incidence of thyroid cancer worldwide, characterized by a highly aggressive and recurrent form of disease. Here, we sought to identify risk factors associated with disease recurrence among Filipinos with WDTC.

Methods

This retrospective cohort study examined 723 patients diagnosed with WDTC seen at Philippine General Hospital. Affected individuals were classified based on the presence or absence of disease recurrence. Multivariate logistic regression analyses were used to determine significant predictors of recurrence.

Results

Multiple risk factors, including age >45 years (odds ratio [OR], 1.44), multifocality of cancer (OR, 1.43), nodal involvement (OR, 4.0), and distant metastases at presentation (OR, 2.78), were significantly associated with a recurrence of papillary thyroid cancer (PTC). In contrast, follicular variant histology (OR, 0.60) and postsurgical radioactive iodine therapy (OR, 0.31) were protective for PTC recurrence. Distant metastases at presentation (OR, 19.4) and postsurgical radioactive iodine therapy (OR, 0.41) were associated with follicular thyroid cancer (FTC) recurrence.

Conclusion

Lymph node metastases at presentation was the strongest predictor of recurrence in PTC, whereas distant metastases at presentation was the strongest for FTC recurrence. Among Filipinos, stratification of WDTC patients based on recurrence risk factors identified in this study will be helpful in guiding the intensity of treatment strategies and long-term thyroid cancer surveillance.

Citations

Citations to this article as recorded by

Characterization of mortality and high-risk characteristics of thyroid cancer in Filipinos using the California Cancer Registry
Robert Hsu, Kai-Ya Tsai, Krithika Chennapan, Katherine Y. Wojcik, Alice W. Lee, Jorge J. Nieva, Lihua Liu
Frontiers in Public Health.2023;[Epub] CrossRef
Behaviour and epidemiology of differentiated thyroid cancer among filipinos in and outside the Philippines: Comparison between Qatar, Canada and Philippines
Mohamed Said Ghali, Walid El Ansari, Abdelrahman Abdelaal, Mohamed S. Al Hassan
Annals of Medicine and Surgery.2022; 81: 104202. CrossRef
Risk Factors for Recurrence of Follicular Thyroid Cancer: A Systematic Review
Mathias Peter Grønlund, Jakob Schmidt Jensen, Christoffer Holst Hahn, Christian Grønhøj, Christian von Buchwald
Thyroid.2021;[Epub] CrossRef
Differential Expression of Non-Coding RNA Signatures in Thyroid Cancer between Two Ethnic Groups
Kristiana Rood, Khodeza Begum, Hanmin Wang, Yan C. Wangworawat, Ryan Davis, Celina R. Yamauchi, Mia C. Perez, Alfred A. Simental, Ria T. Laxa, Charles Wang, Sourav Roy, Salma Khan
Current Oncology.2021; 28(5): 3610. CrossRef
Dynamic Risk Stratification for Predicting Treatment Response in Differentiated Thyroid Cancer
Evanthia Giannoula, Christos Melidis, Nikitas Papadopoulos, Panagiotis Bamidis, Vasilios Raftopoulos, Ioannis Iakovou
Journal of Clinical Medicine.2020; 9(9): 2708. CrossRef
Overall Survival of Papillary Thyroid Carcinoma Patients: A Single‐Institution Long‐Term Follow‐Up of 5897 Patients
Yasuhiro Ito, Akira Miyauchi, Minoru Kihara, Mitsuhiro Fukushima, Takuya Higashiyama, Akihiro Miya
World Journal of Surgery.2018; 42(3): 615. CrossRef
Prognostic value of the 8^th edition of the tumor-node-metastasis classification for patients with papillary thyroid carcinoma: a single-institution study at a high-volume center in Japan
Yasuhiro Ito, Akira Miyauchi, Mitsuyoshi Hirokawa, Masatoshi Yamamoto, Hitomi Oda, Hiroo Masuoka, Hisanori Sasai, Mitsuhiro Fukushima, Takuya Higashiyama, Minoru Kihara, Akihiro Miya
Endocrine Journal.2018; 65(7): 707. CrossRef
The correlations between DNA methylation and polymorphisms in the promoter region of the human telomerase reverse transcriptase (hTERT) gene with postoperative recurrence in patients with thyroid carcinoma (TC)
Jian-Jun Li, Ping Chen Jue-Ru Zheng, Yao-Zong Wang
World Journal of Surgical Oncology.2017;[Epub] CrossRef
Differentiated Thyroid Cancer in Asians
Bo Hyun Kim
Endocrinology and Metabolism.2016; 31(1): 62. CrossRef
Meta-analysis of radiofrequency ablation for treating the local recurrence of thyroid cancers
Q. Zhao, G. Tian, D. Kong, T. Jiang
Journal of Endocrinological Investigation.2016; 39(8): 909. CrossRef

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